Drug interactions
Fluconazole + Saxagliptin-metformin
Severity: Minor
Fluconazole and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is a moderate CYP3A4 inhibitor and may increase saxagliptin exposure. The rise is modest and saxagliptin is generally well tolerated at higher exposure.
What this interaction means in plain words
Fluconazole and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Moderate CYP3A4 inhibition reduces saxagliptin metabolism.
What to do
No routine dose change is needed; monitor for adverse effects and glycemic control, and limit saxagliptin to 2.5 mg only with strong inhibitors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Fluconazole with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Fluconazole and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole is a moderate CYP3A4 inhibitor and may increase saxagliptin exposure. The rise is modest and saxagliptin is generally well tolerated at higher exposure.
How serious is the interaction between Fluconazole and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for adverse effects and glycemic control, and limit saxagliptin to 2.5 mg only with strong inhibitors.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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