Drug interactions
Fluconazole + Secobarbital
Severity: Minor
Fluconazole and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates may reduce fluconazole exposure through enzyme induction, potentially diminishing antifungal efficacy, though the effect is likely modest. Fluconazole may also raise barbiturate levels and sedation.
What this interaction means in plain words
Fluconazole and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate enzyme induction may increase fluconazole clearance; fluconazole inhibits CYP2C19/CYP3A4 metabolism of secobarbital.
What to do
Monitor antifungal response and sedation. Increase the fluconazole dose only if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Fluconazole with Secobarbital?
MediHelp rates the interaction as minor. Fluconazole and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates may reduce fluconazole exposure through enzyme induction, potentially diminishing antifungal efficacy, though the effect is likely modest. Fluconazole may also raise barbiturate levels and sedation.
How serious is the interaction between Fluconazole and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antifungal response and sedation. Increase the fluconazole dose only if response is inadequate.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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