Drug interactions
Fluconazole + Sertraline
Severity: Moderate
Fluconazole and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline has a low but recognized QT effect, and fluconazole also prolongs QT. Combined use may modestly raise arrhythmia risk, and fluconazole may increase sertraline levels through CYP2C19 and CYP3A4 inhibition.
What this interaction means in plain words
Fluconazole and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible increased sertraline exposure from CYP inhibition.
What to do
Check baseline ECG in patients with cardiac risk factors and correct electrolytes. Monitor for serotonergic adverse effects and adjust the sertraline dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Fluconazole with Sertraline?
MediHelp rates the interaction as moderate. Fluconazole and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline has a low but recognized QT effect, and fluconazole also prolongs QT. Combined use may modestly raise arrhythmia risk, and fluconazole may increase sertraline levels through CYP2C19 and CYP3A4 inhibition.
How serious is the interaction between Fluconazole and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG in patients with cardiac risk factors and correct electrolytes. Monitor for serotonergic adverse effects and adjust the sertraline dose if needed.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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