Drug interactions
Fluconazole + Sparsentan
Severity: Moderate
Fluconazole and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase sparsentan exposure, raising the risk of its adverse effects such as hypotension, hyperkalemia, edema and kidney function changes. The effect is generally manageable.
What this interaction means in plain words
Fluconazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Sparsentan belongs to Genitourinary.
Why it happens
Fluconazole inhibits CYP3A4, reducing sparsentan metabolism.
What to do
No dose change is required, but monitor blood pressure, serum potassium, edema and renal function regularly. Also monitor liver enzymes per sparsentan labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Fluconazole with Sparsentan?
MediHelp rates the interaction as moderate. Fluconazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole may increase sparsentan exposure, raising the risk of its adverse effects such as hypotension, hyperkalemia, edema and kidney function changes. The effect is generally manageable.
How serious is the interaction between Fluconazole and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required, but monitor blood pressure, serum potassium, edema and renal function regularly. Also monitor liver enzymes per sparsentan labeling.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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