Drug interactions
Fluconazole + Sufentanil
Severity: Major
Fluconazole and Sufentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is cleared by CYP3A4, and fluconazole can increase its levels, prolonging or intensifying opioid effects. Risks include respiratory depression and prolonged sedation, particularly with repeated or infusion dosing.
What this interaction means in plain words
Fluconazole and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Sufentanil belongs to Musculoskeletal.
Why it happens
Fluconazole inhibits CYP3A4, reducing sufentanil clearance.
What to do
Monitor respiratory rate and sedation closely, and reduce the sufentanil dose or extend dosing intervals as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Fluconazole with Sufentanil?
MediHelp rates the interaction as major. Fluconazole and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sufentanil is cleared by CYP3A4, and fluconazole can increase its levels, prolonging or intensifying opioid effects. Risks include respiratory depression and prolonged sedation, particularly with repeated or infusion dosing.
How serious is the interaction between Fluconazole and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and sedation closely, and reduce the sufentanil dose or extend dosing intervals as needed.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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