Drug interactions
Fluconazole + Tinidazole
Severity: Minor
Fluconazole and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase tinidazole exposure through inhibition of its metabolism. This could increase dose-related adverse effects such as nausea, metallic taste and neurological symptoms, but the effect is generally limited with short courses.
What this interaction means in plain words
Fluconazole and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluconazole belongs to Anti Fungals; Tinidazole belongs to Anti Parasitic.
Why it happens
Fluconazole inhibits CYP3A4, which participates in tinidazole metabolism, so tinidazole levels may rise modestly.
What to do
No routine dose change is needed for standard short courses of tinidazole. Counsel the patient to report neurological symptoms or severe gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Fluconazole with Tinidazole?
MediHelp rates the interaction as minor. Fluconazole and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole may increase tinidazole exposure through inhibition of its metabolism. This could increase dose-related adverse effects such as nausea, metallic taste and neurological symptoms, but the effect is generally limited with short courses.
How serious is the interaction between Fluconazole and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for standard short courses of tinidazole. Counsel the patient to report neurological symptoms or severe gastrointestinal upset.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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