Drug interactions
Fluconazole + Tolazamide
Severity: Moderate
Fluconazole and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can raise tolazamide concentrations and enhance its glucose-lowering effect. This may result in hypoglycemia, which can be prolonged in elderly patients or those with renal impairment.
What this interaction means in plain words
Fluconazole and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Tolazamide belongs to Endocrine.
Why it happens
Fluconazole inhibits CYP2C9, reducing hepatic metabolism of sulfonylureas such as tolazamide.
What to do
Monitor blood glucose closely when starting or stopping fluconazole and reduce the tolazamide dose if hypoglycemia occurs. Educate the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Fluconazole with Tolazamide?
MediHelp rates the interaction as moderate. Fluconazole and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can raise tolazamide concentrations and enhance its glucose-lowering effect. This may result in hypoglycemia, which can be prolonged in elderly patients or those with renal impairment.
How serious is the interaction between Fluconazole and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping fluconazole and reduce the tolazamide dose if hypoglycemia occurs. Educate the patient on hypoglycemia symptoms.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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