Drug interactions
Fluconazole + Verapamil
Severity: Moderate
Fluconazole and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can increase verapamil concentrations, potentiating hypotension, bradycardia and AV block. The risk is greater with higher fluconazole doses, older age or existing conduction disease.
What this interaction means in plain words
Fluconazole and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Verapamil belongs to Cardiovascular.
Why it happens
Fluconazole inhibits CYP3A4, reducing the first-pass and systemic metabolism of verapamil.
What to do
Monitor heart rate, blood pressure and ECG when starting fluconazole, and reduce the verapamil dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Fluconazole with Verapamil?
MediHelp rates the interaction as moderate. Fluconazole and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can increase verapamil concentrations, potentiating hypotension, bradycardia and AV block. The risk is greater with higher fluconazole doses, older age or existing conduction disease.
How serious is the interaction between Fluconazole and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG when starting fluconazole, and reduce the verapamil dose if bradycardia or hypotension develops.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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