Drug interactions
Fluconazole + Vinblastine
Severity: Major
Fluconazole and Vinblastine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may increase vinblastine exposure through CYP3A4 inhibition, raising the risk of neurotoxicity, constipation or ileus, and myelosuppression.
What this interaction means in plain words
Fluconazole and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Vinblastine belongs to Oncology.
Why it happens
Fluconazole inhibits CYP3A4 metabolism of vinblastine.
What to do
Monitor for neuropathy, constipation and neutropenia, and consider vinblastine dose reduction. Prefer a non-interacting antifungal if possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Fluconazole with Vinblastine?
MediHelp rates the interaction as major. Fluconazole and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole may increase vinblastine exposure through CYP3A4 inhibition, raising the risk of neurotoxicity, constipation or ileus, and myelosuppression.
How serious is the interaction between Fluconazole and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, constipation and neutropenia, and consider vinblastine dose reduction. Prefer a non-interacting antifungal if possible.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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