Drug interactions
Fluconazole + Zidovudine
Severity: Moderate
Fluconazole and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole increases zidovudine exposure, which can increase the risk of haematological toxicity such as anaemia and neutropenia, and of nausea or myopathy. The increase is moderate and typically manageable.
What this interaction means in plain words
Fluconazole and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluconazole belongs to Anti Fungals; Zidovudine belongs to Anti Virals.
Why it happens
Fluconazole inhibits zidovudine glucuronidation (UGT2B7), reducing its clearance.
What to do
Monitor full blood count and signs of zidovudine toxicity. Reduce the zidovudine dose or switch to an alternative antiretroviral if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Frequently asked questions
Can I take Fluconazole with Zidovudine?
MediHelp rates the interaction as moderate. Fluconazole and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole increases zidovudine exposure, which can increase the risk of haematological toxicity such as anaemia and neutropenia, and of nausea or myopathy. The increase is moderate and typically manageable.
How serious is the interaction between Fluconazole and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor full blood count and signs of zidovudine toxicity. Reduce the zidovudine dose or switch to an alternative antiretroviral if cytopenias develop.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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