Drug interactions
Fluoxetine + Gepirone
Severity: Major
Fluoxetine and Gepirone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gepirone is a serotonergic antidepressant that is metabolised mainly by CYP3A4 and carries a QT prolongation warning. Combining it with fluoxetine increases the risk of serotonin syndrome and may add to QT effects. The combination of two antidepressants rarely has a justified rationale.
What this interaction means in plain words
Fluoxetine and Gepirone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluoxetine belongs to Central Nervous System; Gepirone belongs to Central Nervous System.
Why it happens
Additive serotonergic activity and additive QT prolongation.
What to do
Avoid concurrent use where possible; if used, obtain an ECG and monitor for serotonin syndrome, stopping one agent if it occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Fluoxetine with Gepirone?
MediHelp rates the interaction as major. Fluoxetine and Gepirone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gepirone is a serotonergic antidepressant that is metabolised mainly by CYP3A4 and carries a QT prolongation warning. Combining it with fluoxetine increases the risk of serotonin syndrome and may add to QT effects. The combination of two antidepressants rarely has a justified rationale.
How serious is the interaction between Fluoxetine and Gepirone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if used, obtain an ECG and monitor for serotonin syndrome, stopping one agent if it occurs.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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