Drug interactions
Fluoxetine + Indacaterol
Severity: Moderate
Fluoxetine and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and indacaterol may cause hypokalemia and tachycardia that increase arrhythmia susceptibility. Risk is higher with cardiac disease, electrolyte disturbances or high doses.
What this interaction means in plain words
Fluoxetine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta2-agonist-induced hypokalemia and sympathetic stimulation.
What to do
Obtain baseline ECG and potassium in patients with cardiac risk factors and correct electrolyte abnormalities. Keep indacaterol at the recommended dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Indacaterol?
MediHelp rates the interaction as moderate. Fluoxetine and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, and indacaterol may cause hypokalemia and tachycardia that increase arrhythmia susceptibility. Risk is higher with cardiac disease, electrolyte disturbances or high doses.
How serious is the interaction between Fluoxetine and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and potassium in patients with cardiac risk factors and correct electrolyte abnormalities. Keep indacaterol at the recommended dose.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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