Drug interactions
Fluoxetine + Loratadine
Severity: Minor
Fluoxetine and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine is a strong CYP2D6 inhibitor and also inhibits CYP3A4 to a lesser degree, so loratadine exposure may rise. Clinical effects are usually limited given loratadine's tolerability.
What this interaction means in plain words
Fluoxetine and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Loratadine belongs to Respiratory.
Why it happens
Fluoxetine and norfluoxetine inhibit CYP2D6 and CYP3A4 metabolism of loratadine.
What to do
No dose adjustment is usually needed; monitor for sedation or other antihistamine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Loratadine?
MediHelp rates the interaction as minor. Fluoxetine and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine is a strong CYP2D6 inhibitor and also inhibits CYP3A4 to a lesser degree, so loratadine exposure may rise. Clinical effects are usually limited given loratadine's tolerability.
How serious is the interaction between Fluoxetine and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for sedation or other antihistamine adverse effects.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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