Drug interactions
Fluoxetine + Melatonin
Severity: Minor
Fluoxetine and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin is metabolized mainly by CYP1A2, and inhibitors of this enzyme can raise its levels and prolong effects such as daytime drowsiness. Fluoxetine's CYP1A2 inhibition is modest, so the effect is generally small.
What this interaction means in plain words
Fluoxetine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Weak inhibition of CYP1A2-mediated melatonin metabolism.
What to do
Start with a low melatonin dose and monitor for excess sedation or next-day drowsiness; reduce the dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Fluoxetine with Melatonin?
MediHelp rates the interaction as minor. Fluoxetine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin is metabolized mainly by CYP1A2, and inhibitors of this enzyme can raise its levels and prolong effects such as daytime drowsiness. Fluoxetine's CYP1A2 inhibition is modest, so the effect is generally small.
How serious is the interaction between Fluoxetine and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low melatonin dose and monitor for excess sedation or next-day drowsiness; reduce the dose if these occur.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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