Drug interactions
Fluoxetine + Rucaparib
Severity: Minor
Fluoxetine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits several CYP enzymes, including CYP2C19, CYP2D6, CYP3A4 and CYP1A2, and fluoxetine is metabolized by CYP2D6 and CYP2C9. Fluoxetine concentrations may rise, but the effect is expected to be modest because of fluoxetine's long half-life.
What this interaction means in plain words
Fluoxetine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibition of CYP2D6 and CYP2C9 may reduce fluoxetine metabolism.
What to do
Monitor for increased fluoxetine adverse effects such as nausea, agitation and tremor, and reduce the fluoxetine dose if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Fluoxetine with Rucaparib?
MediHelp rates the interaction as minor. Fluoxetine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits several CYP enzymes, including CYP2C19, CYP2D6, CYP3A4 and CYP1A2, and fluoxetine is metabolized by CYP2D6 and CYP2C9. Fluoxetine concentrations may rise, but the effect is expected to be modest because of fluoxetine's long half-life.
How serious is the interaction between Fluoxetine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased fluoxetine adverse effects such as nausea, agitation and tremor, and reduce the fluoxetine dose if they appear.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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