Drug interactions
Fluoxetine + Ruxolitinib
Severity: Minor
Fluoxetine and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine is a weak inhibitor of CYP3A4 and norfluoxetine may contribute, so ruxolitinib exposure could increase modestly. This is unlikely to be clinically important at usual doses.
What this interaction means in plain words
Fluoxetine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Ruxolitinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by fluoxetine reducing ruxolitinib clearance.
What to do
No routine dose adjustment is needed; monitor blood counts as is standard for ruxolitinib. Watch for cytopenias or other dose-related adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluoxetine and Ruxolitinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Fluoxetine with Ruxolitinib?
MediHelp rates the interaction as minor. Fluoxetine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine is a weak inhibitor of CYP3A4 and norfluoxetine may contribute, so ruxolitinib exposure could increase modestly. This is unlikely to be clinically important at usual doses.
How serious is the interaction between Fluoxetine and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed; monitor blood counts as is standard for ruxolitinib. Watch for cytopenias or other dose-related adverse effects.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
