Drug interactions
Fluoxetine + Tedizolid
Severity: Moderate
Fluoxetine and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine is an SSRI with a long-lasting active metabolite, and tedizolid weakly inhibits MAO. Serotonin syndrome is theoretically possible, though clinical evidence of harm with tedizolid is scarce.
What this interaction means in plain words
Fluoxetine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Theoretical additive serotonergic effect from weak MAO inhibition plus serotonin reuptake inhibition.
What to do
Monitor for features of serotonin toxicity during the tedizolid course; stopping fluoxetine is not practical because of its long half-life.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluoxetine and Tedizolid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Tedizolid?
MediHelp rates the interaction as moderate. Fluoxetine and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine is an SSRI with a long-lasting active metabolite, and tedizolid weakly inhibits MAO. Serotonin syndrome is theoretically possible, though clinical evidence of harm with tedizolid is scarce.
How serious is the interaction between Fluoxetine and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for features of serotonin toxicity during the tedizolid course; stopping fluoxetine is not practical because of its long half-life.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
