Drug interactions
Fluoxetine + Tiotropium-olodaterol
Severity: Moderate
Fluoxetine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can prolong the QT interval, and long-acting beta2-agonists such as olodaterol can affect heart rate and repolarization, particularly with hypokalemia. Combined use may modestly raise the risk of QT prolongation and arrhythmia, mainly in patients with other risk factors.
What this interaction means in plain words
Fluoxetine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization and heart rate via QT prolongation and beta2-agonist-induced hypokalemia and tachycardia.
What to do
Check baseline ECG and potassium in patients with cardiac disease or other QT-prolonging drugs, and correct electrolyte abnormalities. Use recommended olodaterol doses only.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Fluoxetine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can prolong the QT interval, and long-acting beta2-agonists such as olodaterol can affect heart rate and repolarization, particularly with hypokalemia. Combined use may modestly raise the risk of QT prolongation and arrhythmia, mainly in patients with other risk factors.
How serious is the interaction between Fluoxetine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and potassium in patients with cardiac disease or other QT-prolonging drugs, and correct electrolyte abnormalities. Use recommended olodaterol doses only.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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