Drug interactions
fluoxetine + tramadol
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Serotonin syndrome and seizure risk.
Mechanism of action
Serotonergic synergy; CYP2D6 inhibition.
Clinical management
Avoid or use non-serotonergic analgesic.
Drug reference
References
Frequently asked questions
Can I take fluoxetine with tramadol?
The interaction is rated: Major. Serotonin syndrome and seizure risk.
How serious is the interaction between fluoxetine and tramadol?
The interaction is rated: Major. Evidence level: High.
How is the interaction between fluoxetine and tramadol managed?
Avoid or use non-serotonergic analgesic.
Why do fluoxetine and tramadol interact?
Serotonergic synergy; CYP2D6 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
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