Drug interactions
Fluoxetine + Triclabendazole
Severity: Moderate
Fluoxetine and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may add to the risk of arrhythmia including torsades de pointes. Risk is greater with electrolyte disturbance, bradycardia or underlying heart disease.
What this interaction means in plain words
Fluoxetine and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac repolarization effects.
What to do
Correct potassium and magnesium before treatment and consider a baseline ECG in patients with cardiac risk factors. Triclabendazole is given for a short course, so monitor for palpitations or syncope during that time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Fluoxetine with Triclabendazole?
MediHelp rates the interaction as moderate. Fluoxetine and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may add to the risk of arrhythmia including torsades de pointes. Risk is greater with electrolyte disturbance, bradycardia or underlying heart disease.
How serious is the interaction between Fluoxetine and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before treatment and consider a baseline ECG in patients with cardiac risk factors. Triclabendazole is given for a short course, so monitor for palpitations or syncope during that time.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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