Drug interactions
Fluphenazine + Fluvoxamine
Severity: Moderate
Fluphenazine and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents may prolong the QT interval, and fluvoxamine can inhibit CYP2D6 and CYP1A2 enough to raise fluphenazine levels, increasing sedation and extrapyramidal effects. Rare serotonergic or NMS reactions are also possible.
What this interaction means in plain words
Fluphenazine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive QT prolongation with inhibition of CYP2D6-mediated fluphenazine metabolism.
What to do
Monitor for extrapyramidal symptoms, sedation and ECG changes, and reduce fluphenazine dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Fluvoxamine?
MediHelp rates the interaction as moderate. Fluphenazine and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents may prolong the QT interval, and fluvoxamine can inhibit CYP2D6 and CYP1A2 enough to raise fluphenazine levels, increasing sedation and extrapyramidal effects. Rare serotonergic or NMS reactions are also possible.
How serious is the interaction between Fluphenazine and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and ECG changes, and reduce fluphenazine dose if adverse effects emerge.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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