Drug interactions
Fluphenazine + Gilteritinib
Severity: Moderate
Fluphenazine and Gilteritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib and fluphenazine each can prolong the QT interval, so combining them may increase the risk of torsades de pointes. Patients with electrolyte disturbances or heart disease are at particular risk.
What this interaction means in plain words
Fluphenazine and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Gilteritinib belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Monitor ECG and electrolytes at baseline and during co-therapy, and correct potassium and magnesium. Consider an alternative antipsychotic or dose reduction if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Fluphenazine with Gilteritinib?
MediHelp rates the interaction as moderate. Fluphenazine and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib and fluphenazine each can prolong the QT interval, so combining them may increase the risk of torsades de pointes. Patients with electrolyte disturbances or heart disease are at particular risk.
How serious is the interaction between Fluphenazine and Gilteritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and during co-therapy, and correct potassium and magnesium. Consider an alternative antipsychotic or dose reduction if QTc becomes markedly prolonged.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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