Drug interactions
Fluphenazine + Haloperidol
Severity: Moderate
Fluphenazine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antipsychotics can prolong the QT interval and cause extrapyramidal effects. Combined use increases the risk of arrhythmia and movement disorders without clear benefit.
What this interaction means in plain words
Fluphenazine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive hERG blockade and dopamine D2 antagonism.
What to do
Avoid antipsychotic polypharmacy where possible. If combined, monitor ECG, electrolytes and extrapyramidal symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Fluphenazine with Haloperidol?
MediHelp rates the interaction as moderate. Fluphenazine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both antipsychotics can prolong the QT interval and cause extrapyramidal effects. Combined use increases the risk of arrhythmia and movement disorders without clear benefit.
How serious is the interaction between Fluphenazine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible. If combined, monitor ECG, electrolytes and extrapyramidal symptoms.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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