Drug interactions
Fluphenazine + Hydromorphone
Severity: Moderate
Fluphenazine and Hydromorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine is a phenothiazine antipsychotic with sedative and hypotensive properties. With hydromorphone it can increase drowsiness, orthostatic hypotension and respiratory depression.
What this interaction means in plain words
Fluphenazine and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Hydromorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotension from opioid agonism and antipsychotic dopamine, histamine and alpha-adrenergic blockade.
What to do
Use reduced starting doses of either drug and monitor sedation, blood pressure and respiratory rate. Counsel patients about rising slowly from sitting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Hydromorphone?
MediHelp rates the interaction as moderate. Fluphenazine and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine is a phenothiazine antipsychotic with sedative and hypotensive properties. With hydromorphone it can increase drowsiness, orthostatic hypotension and respiratory depression.
How serious is the interaction between Fluphenazine and Hydromorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced starting doses of either drug and monitor sedation, blood pressure and respiratory rate. Counsel patients about rising slowly from sitting.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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