Drug interactions
Fluphenazine + Indacaterol-glycopyrronium
Severity: Moderate
Fluphenazine and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine is a phenothiazine with anticholinergic activity and QT-prolonging potential. With glycopyrronium, anticholinergic effects may be additive. Indacaterol may add to repolarization effects, raising arrhythmia risk in susceptible patients.
What this interaction means in plain words
Fluphenazine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and additive effects on cardiac repolarization.
What to do
Monitor for anticholinergic effects and obtain an ECG in patients with cardiac risk factors. Correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Fluphenazine and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine is a phenothiazine with anticholinergic activity and QT-prolonging potential. With glycopyrronium, anticholinergic effects may be additive. Indacaterol may add to repolarization effects, raising arrhythmia risk in susceptible patients.
How serious is the interaction between Fluphenazine and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and obtain an ECG in patients with cardiac risk factors. Correct electrolyte disturbances.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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