Drug interactions
Fluphenazine + Lasmiditan
Severity: Moderate
Fluphenazine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan commonly causes dizziness and somnolence, and fluphenazine is also sedating. Combined use may increase drowsiness and impair psychomotor performance and driving ability.
What this interaction means in plain words
Fluphenazine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Counsel the patient to avoid driving or operating machinery for at least 8 hours after each lasmiditan dose. Monitor for excessive sedation and consider a different acute migraine treatment if it is problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Fluphenazine with Lasmiditan?
MediHelp rates the interaction as moderate. Fluphenazine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan commonly causes dizziness and somnolence, and fluphenazine is also sedating. Combined use may increase drowsiness and impair psychomotor performance and driving ability.
How serious is the interaction between Fluphenazine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid driving or operating machinery for at least 8 hours after each lasmiditan dose. Monitor for excessive sedation and consider a different acute migraine treatment if it is problematic.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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