Drug interactions
Fluphenazine + Levomilnacipran
Severity: Moderate
Fluphenazine and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an antipsychotic with a serotonin-norepinephrine reuptake inhibitor may increase the risk of serotonin toxicity, and antipsychotic dopamine blockade may increase the risk of neuroleptic malignant syndrome. Such events are uncommon but can be serious.
What this interaction means in plain words
Fluphenazine and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Levomilnacipran belongs to Central Nervous System.
Why it happens
Additive serotonergic effects and enhanced central dopamine blockade; the exact mechanism is not fully established.
What to do
Monitor for agitation, hyperthermia, tremor, clonus, muscle rigidity and autonomic instability, particularly after dose changes. Stop one or both drugs if serotonin syndrome or neuroleptic malignant syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluphenazine with Levomilnacipran?
MediHelp rates the interaction as moderate. Fluphenazine and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an antipsychotic with a serotonin-norepinephrine reuptake inhibitor may increase the risk of serotonin toxicity, and antipsychotic dopamine blockade may increase the risk of neuroleptic malignant syndrome. Such events are uncommon but can be serious.
How serious is the interaction between Fluphenazine and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, hyperthermia, tremor, clonus, muscle rigidity and autonomic instability, particularly after dose changes. Stop one or both drugs if serotonin syndrome or neuroleptic malignant syndrome is suspected.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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