Drug interactions
Fluphenazine + Lurasidone
Severity: Moderate
Fluphenazine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block dopamine receptors, so combined use raises the risk of extrapyramidal symptoms, sedation and neuroleptic malignant syndrome. Orthostatic hypotension may also be additive.
What this interaction means in plain words
Fluphenazine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive dopamine D2 antagonism and overlapping sedative and alpha-adrenergic blocking effects.
What to do
Use the lowest effective doses and avoid routine combination. Monitor for movement disorders, sedation, orthostatic blood pressure changes and signs of NMS.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Fluphenazine with Lurasidone?
MediHelp rates the interaction as moderate. Fluphenazine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block dopamine receptors, so combined use raises the risk of extrapyramidal symptoms, sedation and neuroleptic malignant syndrome. Orthostatic hypotension may also be additive.
How serious is the interaction between Fluphenazine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid routine combination. Monitor for movement disorders, sedation, orthostatic blood pressure changes and signs of NMS.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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