Drug interactions
Fluphenazine + Midazolam
Severity: Moderate
Fluphenazine and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine is an antipsychotic with sedating properties, and with midazolam it can increase sedation and hypotension. Respiratory depression is possible, especially with higher doses.
What this interaction means in plain words
Fluphenazine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and dopaminergic, antihistaminic and alpha-adrenergic blockade.
What to do
Use a lower midazolam dose and titrate carefully. Monitor sedation, blood pressure and respiration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Midazolam?
MediHelp rates the interaction as moderate. Fluphenazine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine is an antipsychotic with sedating properties, and with midazolam it can increase sedation and hypotension. Respiratory depression is possible, especially with higher doses.
How serious is the interaction between Fluphenazine and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower midazolam dose and titrate carefully. Monitor sedation, blood pressure and respiration.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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