Drug interactions
Fluphenazine + Nabilone
Severity: Moderate
Fluphenazine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so the combination can cause greater drowsiness, dizziness and impaired psychomotor function. Cannabinoids may also worsen psychotic symptoms, and both drugs can affect blood pressure and heart rate.
What this interaction means in plain words
Fluphenazine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression, with possible additive orthostatic hypotension and anticholinergic effects.
What to do
Monitor sedation, blood pressure and psychiatric status, and start nabilone at a low dose. Warn patients against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Nabilone?
MediHelp rates the interaction as moderate. Fluphenazine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so the combination can cause greater drowsiness, dizziness and impaired psychomotor function. Cannabinoids may also worsen psychotic symptoms, and both drugs can affect blood pressure and heart rate.
How serious is the interaction between Fluphenazine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and psychiatric status, and start nabilone at a low dose. Warn patients against driving until the response is known.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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