Drug interactions
Fluphenazine + Selinexor
Severity: Moderate
Fluphenazine and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion, fatigue and other neurological adverse effects. Fluphenazine can cause sedation and dizziness, so the combination may worsen these effects and raise the risk of falls.
What this interaction means in plain words
Fluphenazine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive central nervous system effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation and counsel patients on fall precautions. Reduce the dose or change therapy if neurological symptoms become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Fluphenazine with Selinexor?
MediHelp rates the interaction as moderate. Fluphenazine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion, fatigue and other neurological adverse effects. Fluphenazine can cause sedation and dizziness, so the combination may worsen these effects and raise the risk of falls.
How serious is the interaction between Fluphenazine and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation and counsel patients on fall precautions. Reduce the dose or change therapy if neurological symptoms become troublesome.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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