Drug interactions
Fluphenazine + Solifenacin
Severity: Moderate
Fluphenazine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has anticholinergic activity and can prolong the QT interval, so with solifenacin there is additive risk of anticholinergic toxicity and arrhythmia. Anticholinergics may also reduce the antipsychotic response in some patients.
What this interaction means in plain words
Fluphenazine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive muscarinic antagonism and additive QT prolongation.
What to do
Monitor for constipation, urinary retention, confusion and heat intolerance. Obtain an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Solifenacin?
MediHelp rates the interaction as moderate. Fluphenazine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine has anticholinergic activity and can prolong the QT interval, so with solifenacin there is additive risk of anticholinergic toxicity and arrhythmia. Anticholinergics may also reduce the antipsychotic response in some patients.
How serious is the interaction between Fluphenazine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, urinary retention, confusion and heat intolerance. Obtain an ECG if other QT risk factors are present.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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