Drug interactions
Fluphenazine + Tacrolimus
Severity: Moderate
Fluphenazine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus and fluphenazine can each lengthen the QT interval, so combined use may increase the chance of serious ventricular arrhythmia. Patients with electrolyte imbalance or structural heart disease are at greatest risk.
What this interaction means in plain words
Fluphenazine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check an ECG at baseline and after dose changes, and keep potassium and magnesium within normal range. Reassess the combination if the QTc rises significantly or symptoms such as syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Fluphenazine with Tacrolimus?
MediHelp rates the interaction as moderate. Fluphenazine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus and fluphenazine can each lengthen the QT interval, so combined use may increase the chance of serious ventricular arrhythmia. Patients with electrolyte imbalance or structural heart disease are at greatest risk.
How serious is the interaction between Fluphenazine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG at baseline and after dose changes, and keep potassium and magnesium within normal range. Reassess the combination if the QTc rises significantly or symptoms such as syncope occur.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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