Drug interactions
Fluphenazine + Temazepam
Severity: Moderate
Fluphenazine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking a benzodiazepine hypnotic with a sedating antipsychotic increases drowsiness, dizziness and psychomotor impairment. Falls and next-day impairment are a particular concern in older adults.
What this interaction means in plain words
Fluphenazine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and antipsychotic sedative effects.
What to do
Use the lowest effective temazepam dose and monitor for oversedation and falls. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Fluphenazine with Temazepam?
MediHelp rates the interaction as moderate. Fluphenazine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking a benzodiazepine hypnotic with a sedating antipsychotic increases drowsiness, dizziness and psychomotor impairment. Falls and next-day impairment are a particular concern in older adults.
How serious is the interaction between Fluphenazine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective temazepam dose and monitor for oversedation and falls. Advise patients to avoid driving and alcohol.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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