Drug interactions
Fluphenazine + Ziconotide
Severity: Moderate
Fluphenazine and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide can cause dizziness, confusion and decreased alertness, and these effects may be compounded by sedating antipsychotics. Cognitive impairment and depressed consciousness may be more pronounced.
What this interaction means in plain words
Fluphenazine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depression and cognitive impairment.
What to do
Monitor mental status and level of consciousness, particularly during ziconotide titration. Reduce the dose of either drug if sedation or confusion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Fluphenazine with Ziconotide?
MediHelp rates the interaction as moderate. Fluphenazine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide can cause dizziness, confusion and decreased alertness, and these effects may be compounded by sedating antipsychotics. Cognitive impairment and depressed consciousness may be more pronounced.
How serious is the interaction between Fluphenazine and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status and level of consciousness, particularly during ziconotide titration. Reduce the dose of either drug if sedation or confusion occurs.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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