Drug interactions
Flurbiprofen + Leflunomide
Severity: Moderate
Flurbiprofen and Leflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide's active metabolite inhibits CYP2C9 in vitro and may modestly raise flurbiprofen exposure. Both drugs can also cause hepatic or GI adverse effects.
What this interaction means in plain words
Flurbiprofen and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Leflunomide belongs to Musculoskeletal.
Why it happens
Teriflunomide inhibition of CYP2C9 may reduce flurbiprofen clearance.
What to do
Monitor for NSAID adverse effects, including GI bleeding, and check liver enzymes per leflunomide monitoring schedule.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Leflunomide?
MediHelp rates the interaction as moderate. Flurbiprofen and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leflunomide's active metabolite inhibits CYP2C9 in vitro and may modestly raise flurbiprofen exposure. Both drugs can also cause hepatic or GI adverse effects.
How serious is the interaction between Flurbiprofen and Leflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects, including GI bleeding, and check liver enzymes per leflunomide monitoring schedule.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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