Drug interactions
Flurbiprofen + Ticlopidine
Severity: Moderate
Flurbiprofen and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine may increase flurbiprofen exposure by inhibiting its metabolism. Ticlopidine also impairs platelet function, so combined use adds to NSAID-related bleeding risk.
What this interaction means in plain words
Flurbiprofen and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Ticlopidine belongs to Cardiovascular.
Why it happens
Ticlopidine inhibits CYP2C9 (and CYP2C19) and adds antiplatelet pharmacodynamic effects to NSAID platelet inhibition.
What to do
Monitor for gastrointestinal bleeding and NSAID adverse effects, and use the lowest effective flurbiprofen dose. Consider an alternative analgesic in high bleeding risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Flurbiprofen with Ticlopidine?
MediHelp rates the interaction as moderate. Flurbiprofen and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine may increase flurbiprofen exposure by inhibiting its metabolism. Ticlopidine also impairs platelet function, so combined use adds to NSAID-related bleeding risk.
How serious is the interaction between Flurbiprofen and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal bleeding and NSAID adverse effects, and use the lowest effective flurbiprofen dose. Consider an alternative analgesic in high bleeding risk patients.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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