Drug interactions
Flutamide + Stiripentol
Severity: Moderate
Flutamide and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP1A2 and CYP3A4, both of which are involved in flutamide metabolism. Flutamide exposure may therefore rise or fall, and activation to hepatotoxic metabolites may change. Both drugs may also affect the liver.
What this interaction means in plain words
Flutamide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flutamide belongs to Endocrine; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol has mixed inhibitory and inducing effects on CYP1A2 and CYP3A4, altering flutamide metabolism unpredictably.
What to do
Monitor liver function tests and clinical response to flutamide. Reassess the need for the combination if liver enzymes rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flutamide
Other interactions of Stiripentol
Frequently asked questions
Can I take Flutamide with Stiripentol?
MediHelp rates the interaction as moderate. Flutamide and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces CYP1A2 and CYP3A4, both of which are involved in flutamide metabolism. Flutamide exposure may therefore rise or fall, and activation to hepatotoxic metabolites may change. Both drugs may also affect the liver.
How serious is the interaction between Flutamide and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and clinical response to flutamide. Reassess the need for the combination if liver enzymes rise.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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