Drug interactions
Fluticasone + Rucaparib
Severity: Minor
Fluticasone and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and may modestly raise fluticasone exposure. Clinically significant systemic corticosteroid effects are unlikely with inhaled use.
What this interaction means in plain words
Fluticasone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone belongs to Respiratory; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated fluticasone metabolism by rucaparib.
What to do
No routine adjustment is needed; monitor for signs of systemic corticosteroid excess such as adrenal suppression or Cushingoid features with long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Fluticasone with Rucaparib?
MediHelp rates the interaction as minor. Fluticasone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and may modestly raise fluticasone exposure. Clinically significant systemic corticosteroid effects are unlikely with inhaled use.
How serious is the interaction between Fluticasone and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for signs of systemic corticosteroid excess such as adrenal suppression or Cushingoid features with long-term use.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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