Drug interactions
Fluticasone-salmeterol + Lisdexamfetamine
Severity: Moderate
Fluticasone-salmeterol and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have sympathomimetic activity and together can add to increases in heart rate, blood pressure and palpitations. Patients with cardiovascular disease are most at risk.
What this interaction means in plain words
Fluticasone-salmeterol and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Additive adrenergic stimulation: amphetamine-induced norepinephrine release combined with direct beta-2 agonism by salmeterol.
What to do
Monitor heart rate, blood pressure and arrhythmia symptoms, especially at initiation or dose increases. Reconsider the combination in patients with significant cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have sympathomimetic activity and together can add to increases in heart rate, blood pressure and palpitations. Patients with cardiovascular disease are most at risk.
How serious is the interaction between Fluticasone-salmeterol and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and arrhythmia symptoms, especially at initiation or dose increases. Reconsider the combination in patients with significant cardiovascular disease.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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