Drug interactions
Fluticasone-vilanterol + Hydrochlorothiazide
Severity: Moderate
Fluticasone-vilanterol and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide causes renal potassium loss, and vilanterol can lower potassium further by shifting it into cells. The combination may increase the risk of hypokalemia and arrhythmia in susceptible patients.
What this interaction means in plain words
Fluticasone-vilanterol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hypokalemia from thiazide-induced potassium wasting and beta2-mediated cellular uptake.
What to do
Monitor serum potassium and magnesium, particularly at initiation and in cardiac patients, and supplement if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Fluticasone-vilanterol with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide causes renal potassium loss, and vilanterol can lower potassium further by shifting it into cells. The combination may increase the risk of hypokalemia and arrhythmia in susceptible patients.
How serious is the interaction between Fluticasone-vilanterol and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly at initiation and in cardiac patients, and supplement if low.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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