Drug interactions
Fluticasone-vilanterol + Hydroxychloroquine
Severity: Moderate
Fluticasone-vilanterol and Hydroxychloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine can prolong the QT interval, and vilanterol may add to arrhythmic risk. The effect is usually modest but matters in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Fluticasone-vilanterol and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
Additive QTc prolongation with beta-agonist-related hypokalemia.
What to do
Check baseline ECG in patients with cardiac risk factors and monitor potassium and magnesium. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Hydroxychloroquine?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Hydroxychloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxychloroquine can prolong the QT interval, and vilanterol may add to arrhythmic risk. The effect is usually modest but matters in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Fluticasone-vilanterol and Hydroxychloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG in patients with cardiac risk factors and monitor potassium and magnesium. Avoid adding other QT-prolonging drugs.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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