Drug interactions
Fluticasone-vilanterol + Idelalisib
Severity: Major
Fluticasone-vilanterol and Idelalisib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can raise exposure to vilanterol and fluticasone furoate. This may lead to increased beta-agonist cardiovascular effects and systemic corticosteroid effects such as adrenal suppression.
What this interaction means in plain words
Fluticasone-vilanterol and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A inhibition reducing clearance of vilanterol and fluticasone furoate.
What to do
Avoid the combination where possible; consider an inhaled steroid and bronchodilator less dependent on CYP3A. If used, monitor heart rate, potassium and signs of corticosteroid excess.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Zydelig 100 mg Film-coated Tablets - SmPC sections 4.3/4.5 (names the partner; "Inhaled/nasal corticosteroids: Budesonide, fluticasone") — electronic medicines compendium (UK SmPC)
Other interactions of Fluticasone-vilanterol
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Idelalisib?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and can raise exposure to vilanterol and fluticasone furoate. This may lead to increased beta-agonist cardiovascular effects and systemic corticosteroid effects such as adrenal suppression.
How serious is the interaction between Fluticasone-vilanterol and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; consider an inhaled steroid and bronchodilator less dependent on CYP3A. If used, monitor heart rate, potassium and signs of corticosteroid excess.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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