Drug interactions
Fluticasone-vilanterol + Lopinavir
Severity: Major
Fluticasone-vilanterol and Lopinavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, given with ritonavir, strongly inhibits CYP3A4, which can raise exposure to vilanterol and fluticasone furoate. Lopinavir may also prolong QT, so cardiovascular beta-agonist effects and systemic steroid effects may both be increased.
What this interaction means in plain words
Fluticasone-vilanterol and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition (via ritonavir boosting) plus additive QT effects.
What to do
Avoid the combination if possible and consider beclomethasone-based therapy. If unavoidable, monitor ECG, potassium and signs of Cushingoid effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Lopinavir?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Lopinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lopinavir, given with ritonavir, strongly inhibits CYP3A4, which can raise exposure to vilanterol and fluticasone furoate. Lopinavir may also prolong QT, so cardiovascular beta-agonist effects and systemic steroid effects may both be increased.
How serious is the interaction between Fluticasone-vilanterol and Lopinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and consider beclomethasone-based therapy. If unavoidable, monitor ECG, potassium and signs of Cushingoid effects.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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