Drug interactions
Fluticasone-vilanterol + Ondansetron
Severity: Moderate
Fluticasone-vilanterol and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron prolongs the QT interval in a dose-related way, and beta-2 agonists can add tachycardia and hypokalemia. The combination could increase the risk of arrhythmia in susceptible patients.
What this interaction means in plain words
Fluticasone-vilanterol and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-vilanterol belongs to Respiratory; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation and adrenergic cardiac stimulation.
What to do
Correct potassium and magnesium and avoid high-dose intravenous ondansetron in patients with QT risk factors; monitor ECG in those at risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Fluticasone-vilanterol with Ondansetron?
MediHelp rates the interaction as moderate. Fluticasone-vilanterol and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ondansetron prolongs the QT interval in a dose-related way, and beta-2 agonists can add tachycardia and hypokalemia. The combination could increase the risk of arrhythmia in susceptible patients.
How serious is the interaction between Fluticasone-vilanterol and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium and avoid high-dose intravenous ondansetron in patients with QT risk factors; monitor ECG in those at risk.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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