Drug interactions
Fluticasone-vilanterol + Ozanimod
Severity: Minor
Fluticasone-vilanterol and Ozanimod: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and affect conduction, while vilanterol is a beta-2 agonist that can cause tachycardia, hypokalemia and QT changes. The combination has unpredictable cardiac effects, and the clinical significance of inhaled use is uncertain.
What this interaction means in plain words
Fluticasone-vilanterol and Ozanimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-vilanterol belongs to Respiratory; Ozanimod belongs to Central Nervous System.
Why it happens
Opposing and additive effects on heart rate and cardiac repolarization; the mechanism is not firmly established.
What to do
Monitor heart rate and ECG when starting ozanimod in patients using vilanterol. Check potassium if palpitations or arrhythmia symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Ozanimod?
MediHelp rates the interaction as minor. Fluticasone-vilanterol and Ozanimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ozanimod can slow heart rate and affect conduction, while vilanterol is a beta-2 agonist that can cause tachycardia, hypokalemia and QT changes. The combination has unpredictable cardiac effects, and the clinical significance of inhaled use is uncertain.
How serious is the interaction between Fluticasone-vilanterol and Ozanimod?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG when starting ozanimod in patients using vilanterol. Check potassium if palpitations or arrhythmia symptoms occur.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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