Drug interactions
Fluticasone-vilanterol + Rucaparib
Severity: Minor
Fluticasone-vilanterol and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak-to-moderate CYP3A inhibitor and may modestly raise exposure to inhaled fluticasone furoate and vilanterol. Because inhaled systemic exposure is low, a clinically meaningful effect is unlikely in most patients.
What this interaction means in plain words
Fluticasone-vilanterol and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-vilanterol belongs to Respiratory; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, reducing the first-pass and systemic clearance of fluticasone furoate and vilanterol.
What to do
No routine dose change is needed; monitor for beta-agonist effects such as tachycardia and tremor, and for corticosteroid systemic effects if used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Fluticasone-vilanterol with Rucaparib?
MediHelp rates the interaction as minor. Fluticasone-vilanterol and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak-to-moderate CYP3A inhibitor and may modestly raise exposure to inhaled fluticasone furoate and vilanterol. Because inhaled systemic exposure is low, a clinically meaningful effect is unlikely in most patients.
How serious is the interaction between Fluticasone-vilanterol and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for beta-agonist effects such as tachycardia and tremor, and for corticosteroid systemic effects if used long term.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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