Drug interactions
Fluticasone-vilanterol + Sotalol
Severity: Major
Fluticasone-vilanterol and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a non-selective beta-blocker that directly opposes the bronchodilating effect of vilanterol and may trigger bronchospasm in patients with asthma or COPD. Sotalol also prolongs the QT interval, and beta-2 agonists can add to this through tachycardia and hypokalemia.
What this interaction means in plain words
Fluticasone-vilanterol and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Sotalol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta-2 receptors, together with additive QT-prolonging and proarrhythmic effects.
What to do
Avoid sotalol in patients with obstructive airway disease who need a beta-agonist; consider another antiarrhythmic. If it is unavoidable, monitor respiratory status, ECG and potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluticasone-vilanterol
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Sotalol?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is a non-selective beta-blocker that directly opposes the bronchodilating effect of vilanterol and may trigger bronchospasm in patients with asthma or COPD. Sotalol also prolongs the QT interval, and beta-2 agonists can add to this through tachycardia and hypokalemia.
How serious is the interaction between Fluticasone-vilanterol and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sotalol in patients with obstructive airway disease who need a beta-agonist; consider another antiarrhythmic. If it is unavoidable, monitor respiratory status, ECG and potassium and magnesium.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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