Drug interactions
Fluticasone-vilanterol + Stiripentol
Severity: Minor
Fluticasone-vilanterol and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so exposure to the inhaled components could rise or fall. The net effect on inhaled fluticasone furoate and vilanterol is unpredictable and probably small given low systemic exposure.
What this interaction means in plain words
Fluticasone-vilanterol and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-vilanterol belongs to Respiratory; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol variably inhibits and induces CYP3A4, altering metabolism of fluticasone furoate and vilanterol.
What to do
Monitor for loss of asthma/COPD control or for beta-agonist and corticosteroid adverse effects after starting or stopping stiripentol; no empiric dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-vilanterol
Other interactions of Stiripentol
Frequently asked questions
Can I take Fluticasone-vilanterol with Stiripentol?
MediHelp rates the interaction as minor. Fluticasone-vilanterol and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol has both inhibitory and inducing effects on CYP3A4, so exposure to the inhaled components could rise or fall. The net effect on inhaled fluticasone furoate and vilanterol is unpredictable and probably small given low systemic exposure.
How serious is the interaction between Fluticasone-vilanterol and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of asthma/COPD control or for beta-agonist and corticosteroid adverse effects after starting or stopping stiripentol; no empiric dose change is required.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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