Drug interactions
Fluticasone-vilanterol + Trimipramine
Severity: Major
Fluticasone-vilanterol and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists and also prolong the QT interval. Combined use may cause tachycardia, hypertension or arrhythmia.
What this interaction means in plain words
Fluticasone-vilanterol and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone-vilanterol belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive adrenergic cardiovascular stimulation and QT prolongation, with tricyclic inhibition of noradrenaline reuptake.
What to do
Avoid if possible, or use only with ECG, blood pressure and heart rate monitoring. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Fluticasone-vilanterol with Trimipramine?
MediHelp rates the interaction as major. Fluticasone-vilanterol and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists and also prolong the QT interval. Combined use may cause tachycardia, hypertension or arrhythmia.
How serious is the interaction between Fluticasone-vilanterol and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or use only with ECG, blood pressure and heart rate monitoring. Correct potassium and magnesium abnormalities.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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